Indomethacin is a prescription anti‑inflammatory drug that belongs to the NSAID family. Doctors usually pick it for tough pain and swelling that other meds haven’t fixed, such as gout attacks, ankylosing spondylitis, and certain types of arthritis. If you’ve ever wondered why a doctor wrote indomethacin on the pad, it’s because the drug works fast to cut inflammation and bring relief.
The drug comes in several forms: tablets, capsules, and a liquid suspension for people who can’t swallow pills. The most common starting dose for an adult with gout is 50 mg three times a day, but doctors can adjust it based on the condition and how you respond. For chronic arthritis, the dose might be lower, like 25 mg two or three times daily, and the goal is to use the smallest amount that keeps symptoms under control.
Because indomethacin can irritate the stomach, most prescribers recommend taking it with food or a full glass of milk. If you have a history of ulcers, your doctor may add a protective medicine like a proton‑pump inhibitor. Always follow the exact schedule—missing a dose doesn’t mean you should double up; just take the next dose at the usual time.
First, double‑check the label for any extra instructions. Some brands ask you to stay upright for 30 minutes after swallowing to reduce the chance of heartburn. Keep a water bottle handy; staying hydrated helps your kidneys handle the drug better. Avoid alcohol while on indomethacin because it can boost stomach irritation and raise bleeding risk.
Don’t mix indomethacin with other NSAIDs like ibuprofen or naproxen—doing so piles up the same side effects. Over‑the‑counter pain relievers that contain aspirin should also be avoided unless your doctor says otherwise. If you’re on blood thinners, talk to your prescriber; indomethacin can make bleeding more likely.
The most common complaints are stomach upset, nausea, and a feeling of fullness. If you notice black or tarry stools, vomiting blood, or severe stomach pain, call your doctor right away—those are signs of a possible bleed. Headaches, dizziness, and ringing in the ears can also happen, especially at higher doses.
Kidney problems are a rarer but serious risk. Watch for reduced urine output, swelling in your ankles, or sudden weight gain. If any of these pop up, get medical help quickly. Most side effects improve when you lower the dose or add a protective medication, but never change the dose on your own.
Because indomethacin can affect blood pressure, people with hypertension should have their pressure checked regularly. If you’re pregnant or planning to become pregnant, discuss alternatives with your doctor, as indomethacin isn’t recommended in the later stages of pregnancy.
Regular follow‑up appointments let your provider monitor liver enzymes, kidney function, and any signs of gastrointestinal trouble. Having a simple blood test every few months helps catch issues before they become serious. If you ever feel unsure about a symptom, err on the side of caution and give your clinic a call.
Bottom line: indomethacin can be a powerful ally for painful inflammation, but it works best when you respect the dosing schedule, protect your stomach, stay hydrated, and keep an eye on side effects. Use it exactly as prescribed, and you’ll likely enjoy faster relief with fewer hassles.
Sep, 11 2025
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