Sulindac: What It Is, How It Works, and Who Should Use It

Sulindac is a non‑steroidal anti‑inflammatory drug (NSAID) that helps lower pain and swelling. It blocks enzymes called COX‑1 and COX‑2, which are behind the inflammation you feel in joints or after an injury. People usually turn to sulindac for arthritis, back pain, or mild to moderate muscle aches.

If you’ve been prescribed sulindac, you probably wonder how often to take it and what to watch out for. Below you’ll find the most practical advice, not a lot of medical jargon.

How to Take Sulindac Safely

Take sulindac exactly as your doctor tells you. The usual adult dose is 150 mg twice a day, but some doctors start with 100 mg if you’re sensitive to stomach issues. Swallow the tablet whole with a full glass of water; don’t crush or chew it.

Always take sulindac with food or milk. That simple step can cut stomach upset by half. If you miss a dose, take it as soon as you remember—unless it’s almost time for the next one. In that case, skip the missed dose; don’t double up.

Watch your other meds. Sulindac can interact with blood thinners, certain blood pressure drugs, and other NSAIDs. If you’re on a prescription for aspirin, warfarin, or a diuretic, let your doctor know before you start sulindac.

Stay hydrated. Drinking plenty of water helps your kidneys clear the drug and lowers the risk of kidney irritation. If you have a history of kidney problems, ask your doctor whether sulindac is safe for you.

Common Side Effects & When to Call a Doctor

Most people tolerate sulindac well, but a few side effects are common:

• Stomach pain or heartburn
• Nausea or mild vomiting
• Headache
• Dizziness

If any of these get worse or don’t improve after a few days, call your doctor. More serious signs need immediate attention:

• Blood in stools or black, tar‑like stools
• Sudden vision changes or ringing in the ears
• Swelling of the ankles, feet, or hands
• Shortness of breath or chest pain

These could mean bleeding, kidney trouble, or an allergic reaction. Stop taking sulindac right away and seek medical help.

Pregnant or nursing moms should avoid sulindac unless a doctor says it’s absolutely necessary. The drug can affect the baby’s heart and kidneys.

For older adults, the dose may need to be lower because kidneys don’t work as efficiently with age. Your doctor may start you on a reduced amount and monitor blood tests.

Lastly, keep a simple log of when you take sulindac, what you eat, and any side effects you notice. This record helps your doctor fine‑tune the dose or decide if another medication works better.

In a nutshell, sulindac can be a solid option for pain and inflammation if you follow the dosing guide, take it with food, stay hydrated, and know the red‑flag symptoms. When in doubt, a quick call to your healthcare provider can keep you on the right track.